Cairo used to be Huey's best friend when Huey lived in Chicago. After Huey left, Cairo became best friends with Dewey Jenkins. In the episode


Wingmen it is revealed that Cairo holds a deep resentment towards Huey for leaving Chicago. He insults Huey, causing them to get into a fight. Through this episode, he failed to understand Huey and he failed to make peace with him. Later, Huey comes to his house to apologize, but Cairo headbutts him off the porch and thus ending his friendship with Huey.