The Lethal Interjection Crew is a crew started by Thugnificent and his homies Macktastic and Flo.
- Otis Jenkins, stage name Thugnificent (voiced by Carl Jones): A once-famous rapper and Riley Freeman's most recent idol, Thugnificent hails from the fictional town of Terra-Belle,Georgia. He is loud-mouthed and sports afro puffs.
- Macktastic (voiced by Snoop Dogg): A rapper, and member of Thugnificent's Lethal Interjection crew.
- Flonominal, real name Derick (voiced by Busta Rhymes): A rapper, and member of Thugnificent's Lethal Interjection crew. He resigns from the Lethal Interjection in "Bitches to Rags" when Thugnificent is unable to pay for the house and when Thugnificent gets him fired from a job as an office worker. In this episode, however, he is not voiced by Busta Rhymes.
- Leonard (voiced by DeRay Davis): Thugnificent's dim yet well-meaning friend and member of Thugnificent's Lethal Interjection Crew. Although Leonard was treated as a second-class member of the Lethal Interjection Crew -- mostly due to his penchant for being socially awkward -- he is the only member of the crew to stick with Thugnificent when he lost all of his money.
|Main Characters||Huey • Riley • Grandad • Ruckus • Tom • Sarah • Jazmine • Michael|
|Recurring Characters||Ed Wuncler • Eddie Wuncler •Ed Wuncler lll • Gin Rummy • A Pimp Named Slickback • Thugnificent • Sitnkmeaner • Cindy McPhearson • Gangstalicious • Bushido Brown • Rev. Rollo Goodlove • Lethal Interjection Crew|
|Other Characters||Cairo • Dewey Jenkins • Hiro Otomo • Phil • Cookie Freeman • Jericho Freeman • The Hateocracy • Moe Jackson • Cristal • Luna • Ebony Brown • Ming • Mrs. Von Hausen • Butch Magnus • Lamilton Taeshawn • Devil • Shabazz K. Milton Berle • Catcher Freeman • Xzibit • Martin Luther King Jr. • Wedgie Ruldin • Deborah Leevil • Winston Jerome • Jimmy Rebel • Mr. Uberwitz • Sway Colloway • Dr. Doomis • The Booty Warrior • Lando Freeman • Ruckus Family • Big Nigga • Crazy Bitch • Pretty Boy Flizzy • Boss Willona • Geraldine • Kardashia|